Disseminated intravascular coagulation(DIC) in a patient with undifferenciated carcinoma of the submandibular gland: Report of a case.

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DIC (Disseminated intravascular coagulation) in a patient with undifferenciated adenocarcinoma of the submandibular gland was reported. The patient was a 74-year-old man referred to our hospital because of swelling at the right submandibular region. DIC was found hematologically eight days after radiation. The platelet count decreased to 65×103/μl, fibrinogen decreased to 164 mg/ml and fibrin and fibrinogen degradation produsts (FDP) increased to 40μg/ml. At first treatment was daily performed with continuous heparin-drip (12, 000 U/day), and then gabexate mesilate (1, 200 mg/day) was administrated during 29 days. As a result of this treatment, hemostatic improvement was obtained. Discussion was also made concerning the diagnosis, treatment and cause of DIC and in addition the reports of DIC in oral and maxillofacial surgery were reviewed.
社団法人日本口腔外科学会の論文