The effect of combination treatment with calcium channel blocker and antitumor drugs in vitro. Time table of the administration of calcium channel blocker.:Time table of the administration of calcium chamel blocker

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概要

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• The ability of verapamil (VER), a calcium blocker, to enhance the antitumor action of adriamycin (ADR) and peplomycin (PEP) was studied <I>in vitro</I>. As compared with ADR treatment only, antiproliferative effects of ADR were enhanced in a human myelogenous leukemia cell line (K-562 cells) and a human squamous cell carcinoma cell line (HSC-3 cells) by simultaneous treatment with VER and ADR. Simultaneous administration of VER and PEP also enhanced the antiproliferative effects of PEP in HSC-3 cells. Moreover, in comparison with simultaneous treatment with VER and ADR in K-562 cells, the antiproliferative effects of ADR were further enhanced by one hour subsequent treatment with VER. Similar enhancement was shown in HSC-3 cells by two hours subsequent VER treatment.<BR>However, when VER was added to HSC-3 cells for more than two hours subsequent to PEP administration, antiproliferative effect were lower than those induced by simultaneous VER and PEP treatment.<BR>In comparison, thirty minutes pretreatment with VER decreased the antiproliferative effect of ADR in HSC-3 cells.<BR>These results suggest that VER is able to enhance the antiproliferative effects of ADR and PEP <I>in vitro</I>; it appears that the time of VER administration may play an important role in the enhancement of the antiproliferative effects of ADR and PEP.

• 社団法人 日本口腔外科学会の論文

著者

• 野阪 泰弘

  大阪歯科大学

• 野阪 泰弘

  大阪歯科大学口腔外科学教室第2講座

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• The effect of combination treatment with calcium channel blocker and antitumor drugs in vitro. Time table of the administration of calcium channel blocker.:Time table of the administration of calcium chamel blocker

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