顎骨内嚢胞形成性疾患におけるFlomoxef Sodium (FMOX) の組織移行性に関する臨床的検討

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Flomoxef sodium (FMOX), a new oxacephem antibiotic, was preoperatively administrated by i.v. drip infusion in patients with cyst formation in the jaw. Then the concentrations of FMOX in serum, bone, cyst wall or cyst-like structure in the jaws, and its content, all collected during operation, were examined. The results were as follows.<BR>1. Mean concentrations of FMOX in serum, bone, cyst wall or cyst-like structure, and its content at a dose of 1g were 17.66, 3.03, 8.88, and 3.45 μg/ml.g, respectively. At a dose of 2g, those were 31.27, 6.46, 15.74 and 9.12 μg/ml.g, respectively. Mean concentrations at a dose of 2g were almost twice as high as those at a dose of 1g.<BR>2. Mean ratios of the antibiotic transferred into the bone, cyst wall or cyst-like structure, and its content to that in serum, were 18.39, 52.64, and 24.31%, respectively in the patients recieved 1g FMOX injection. The corresponding ratios were 20.29, 51.87, and 29.26% in those recieved 2g FMOX injection. These patients in the two dosing groups showed almost the same degree of transfer.<BR>3. When the degree of FMOX transfer into the cystic content was examined according to the histopathological type, it was highest in the radicular cyst, being about 3-to 4 fold these of other histological types.