FDG-PET/CT検査における物理学的指標に基づいた収集時間の最適化

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Purpose: The image quality of Positron Emission Tomography (PET) using 18F-fluoro-2-deoxy-D-glucose is extremely important to diagnose cancer precisely. The purpose of this study is to inspect the physical indexes that are correlated with image quality and optimization of the scan time, utilizing the physical index. Methods: This study calculated two kinds of patient noise equivalent counts (NECpatient and NECdensity) and signal to noise ratio in liver (SNRliver) to measure PET image quality. We estimated the correlation coefficient between the visual assessment of PET image quality and physical indexes to assess the degree of correlation. We also set the optimal scan time, depending on body mass index (BMI), using the physical index and examined the efficacy of the optimization. Results: NECdensity showed the highest correlation coefficient in PET image quality (r=0.743, p<0.001). By optimizing the scan time using NECdensity, we showed there was no correlation between BMI and NECdensity (r=0.192, p=0.047). In addition, reduced dependence of the PET image quality by BMI was showed. Conclusion: The optimization of the scan time using NECdensity reduces deterioration of the PET image quality by patient habitus.