An experimental study of hydroxylapatite implants in 60Co irradiated bone.

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The purpose of this study was to evaluate the application of hydroxylapatite (HA) implants in 60Co irradiated bone. Fifty-two adult male rabbits were used for the experiment. HA was implanted in the mandible 3 months (3 M group), 6 months (6 M group) and 12 months (12 M group) after application of 15 Gy of irradiation from a 60Co source. Nonirradiated animals served as controls. The animals were sacrificed 7, 14, 30, 60 and 90 days after HA implantation. Healing processes were examined by contact microradiography, fluorescent labeling with bone markers (tetracycline and calcein), and histologically with HE stain. The following results were obstained: 1. HA-bone fusion occurred on the 7th day in the control, 6 M and 12 M groups, and on the 30th day in the 3 M group. 2. Bone fusion with almost the entire HA surface occurred on the 30th day in the controls, 60th day in the 6 M and 12 M groups, and 90th day in the 3 M group. 3. Trabecular bone around the implant decreased from the 30th day in the control, 6 M and 12 M groups, and on the 60th day in the 3 M group. 4. These results indicate that the application of hydroxylapatite dental implants to irradiated bone should be performed as late as possible after tradiation. The healing period after implantation needs to be as long as possible. In addition, cortical bone should contribute more to the retention of HA than trabecular bone because a long healing period causes a decrease in travecular bone around the implant.

An experimental study of hydroxylapatite implants in 60Co irradiated bone.

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