口腔細胞診の有用性に関する検討-偽陰性症例の原因について-

概要

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In spite of its important role in the detection and diagnosis of malignant lesions in various fields, cytology is not highly appreciated in oral lesions because of its relatively high false-negative rate and because of easy application of biopsy. The authors investigated the causes of false-negative cytology in order to re-evaluate the usefulness of smear cytology in oral malignant lesions. Subjects were false negative cases from 241 oral smear cytology of malignant tumors performed in the Department of Head and Neck of the Cancer Institute Hospital from 1985-1990. The results were as follows: 1. False-negative cytology was found to result from technical errors (29 cases, 45.4%), natures of diseases (24 cases, 37.5%) and misdiagnosis (1 case, 1.5%). No special causes could be found in the remaining ten cases. 2. The types of technical errors were as follows: errors in scrubbing (24 cases) and drying of specimens (5 cases). 3. The clinical pictures of false-negative cases due to natures of lesions were leukoplakia type (21 cases), papillomatous type (2 cases) and granulous type (1 case). The present results suggested it is possible to reduce the incidence of false-negative cytology by using adequate techniques, selecting subjects and improving diagnostic competence.
社団法人日本口腔外科学会の論文