口腔扁平上皮癌におけるp53癌抑制遺伝子産物の免疫組織化学的検索 : PCNA染色との比較および臨床病理学的関連性について

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The present paper reports the expression of tumor suppressor gene product p53 in biopsy specimens obtained from 40 cases of oral squamous cell carcinoma, studied by optimal immunohistochemical technique. The results are compared with those derived by immunohistochemical detection of PCNA (PC 10) and their relation ship with clinicopathologic findings is also described.<BR>Immunohistochemical expression with monoclonal antibodies (BP 53-12) to p53 showed positive staining in 21 cases (52%).<BR>In these cases, evidence of p53 was significantly correlated with positive reaction to PCNA (P<0.01).<BR>Moreover, the expression of p53 was positively correlated with histopathological signs of malignancy such as the mode of invasion and degree of histological differentiation.
社団法人日本口腔外科学会の論文