A case of a submandibular recurrence of mandibular gingival carcinoma successfully treated by hyperthermia with local vasoconstrictor injection.

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Hyperthermia (HT) combined with local vasoconstrictor injection (LVI) was used to treat a recurrent carcinoma of the mandibular gingiva, and resulted in a complete response.<BR>A 65-year-old man with a postoperative recurrent carcinoma of the mandibular gingiva received radiofrequency capacitive HT combined with i. v. injection of CDDP (10mg) and PEP (5 mg) following <SUP>60</SUP>Co irradiation (3 Gy). HT combined with LVI was used for treatment. After injection of 1% lidocaine containing 0.01% epinephrine (10ml) around the tumor, HT was performed. The tumor temperature was increased to over 42°C and remained at this level for 40 minutes without pain or side effects. After treatment the tumor decreased in size and pain disappeared. On CT, a low density area was observed inside of the tumor after the completion of HT, and the tumor disappeared completely 3 months later.<BR>The results suggest that decreased blood flow causes an effective elevation of temperature and acidification of tumor tissue which in turn enhances the thermal sensitivity of the tumor.