両側性耳下腺 Warthin 腫瘍の1例-免疫組織化学的所見を中心に-

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Warthin tumor is a relatively rare tumor that occurs exclusively in the parotid gland, occasionally bilaterally.<BR>The case presented is a 53-year-old man with the chief complaint of bilateral swelling, slowly increasing with no pain, of the parotid glands. Histopathological study of the enucleated tumors revealed papillary or tubular proliferation of columnar and cuboidal epithelium cells arranged in bilayers associated with stromal lymphoid tissue in the cystic cavity. The histopathological diagnosis was Warthin tumor. The postoperative course has shown no evidence of recurrence.<BR>Immunohistochemically, B-cells showed a positive reaction right below the epithelium and T-cells were scattered in the stromal lymphoid tissue, with the former being predominant. Likewise, IgG, IgM, and IgA were sporadically noted in the stromal lymphoid tissue, with IgG being predominant. In addition, positive reactions for IgA and secretory component (SC) were seen in the cytoplasm of the tubular epithelium. The results suggested the presence of an SC-mediated transport mechanism.
社団法人日本口腔外科学会の論文