Eiseninの化学的構造に対するヂケトピペラヂン説の検討-1-

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These experiments were tried to clarify the problem proposed by Dr. Y. TAZAWA about the chemical structure of eisenin, and it has been thought to be true that the chemical structure of eisenin is l-pyrrolidonoyl-α-l-glutaminyl-l-alanine as it was reported by OHIRA, one of the authers, previously, according to the following experimental results. 1. The diketopiperazine reactions were examined upon eisenin, its related substances and typical diketopiperazines, with o-dinitrobenzene, m-dinitrobenzen and picric acid as the reagents for the reactions, and the reaction color of eisenin was found to be positive only in the case of using m-dinitrobenzen, but the reaction color was too weak to be recognized as the diketopierazine reaction. 2. The weak reaction of diketopiperazine was given by synthetic l-pyrrolidonoyl-α-l-glutamyl-diamide, i.e. the analogous substance of eisenin, but the reaction was not brought about at all by l-pyrrolidonoyl-α-l-glutamyl-diethy lester from which the diamide mentioned above was made. 3. The peptide which was yielded by ammonolysis of 5-methyl-1-[l-pyrrolidonoyl-α-l-glutaminyl]-2-thiohydantion derived from eisenin was exactly identical with synthetic l-pyrrolidonoyl-α-l-glutamyl-diamide considering the comparison of their X-ray diffraction diagrams.
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