5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal
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概要
- 論文の詳細を見る
Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitartrate or equimolar sodium tartrate was infused into each rat via a s.c. osmotic minipump for 7 days. Somatic abstinence signs (teeth-chattering/chews and shakes, etc.) were counted one day after pump removal. Somatic signs were attenuated by the i.p. injection of 5-HTP, but not by NSD-1015, a centrally-acting L-aromatic amino acid decarboxylase inhibitor, indicating that 5-HTP mitigates somatic signs mainly through its conversion to 5-HT.
著者
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DOMINO Edward
Department of Pharmacology, University of Michigan
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Yoshioka Mitsuhiro
Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine
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Ohmura Yu
Department of Pharmacology, University of Michigan, USA
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Jutkiewicz Emily
Department of Pharmacology, University of Michigan, USA
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Jutkiewicz Emily
Department Of Pharmacology University Of Michigan Medical School
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Domino Edward
Department Of Pharmacology University Of Michigan
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Ohmura Yu
Department Of Neuropharmacology Hokkaido University Graduate School Of Medicine
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Ohmura Yu
Department Of Pharmacology University Of Michigan
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Jutkiewicz Emily
Department Of Pharmacology University Of Michigan
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