Diagnosis and treatment of melanoma. Recent topics.

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Recent advances in the diagnosis and treatment of malignat melanoma were described in this review. Two newly developed instruments surely increase diagnostic accuracy and preoperative evaluation of primary lesions of malignant melanoma. One is epiluminescence microscopy using a dermatoscope or a videomicroscope, which gives us magnified features of various kinds of pigmented skin lesions. The other is high frequency sonography, which gives us information about tumor thickness of the primary lesions, the most important prognostic factor. Regarding treatment of melanoma, the concept of sentinel node biopsy may have great impact on the issues of elective lymph node dissection. Significance of interferon as a postoperative adjuvant therapy for high-risk patients was discussed. Recent data on the effects of the combination chemotherapy including tamoxifen and sequential biochemotherapy using IL-2 and interferon were briefly reviewed. Finally, several types of new treatment such as immuno-gene therapy based on the development of molecular biology was discussed.
日本皮膚悪性腫瘍学会の論文