Studies on the mechanism of liver injury by lymphokine-activated killer cell.
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Normal peripheral blood mononuclear cells which were cultured with a lymphokine, recombinant interleukin 2 (IL2), for 72 hours developed lytic activity for natural killer-resistant Daudi cells. Lymphokine-activated killer (LAK) cells were thought to produce some cytolytic substance, because the culture supernatant from IL2-mediated mononuclear cells which were coclutured with Duadi cells caused on injury of Daudi cells as well as isolated hepatocytes. The active factor contained in the culture supernatant was found to be a protein having a molecular weight of 10 to 40K daltons. The activity was diminished by trypsin digestion but not by RNase, DNase or neuraminidase treatment. The active factor was rather stable to heat treatment.
- 財団法人 日本消化器病学会の論文
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