Effect of tetragastrin on prostaglandin release into gastric lumen in humans.

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Effect of tetragastrin on endogenous prostaglandins (PGs) in human gastric juice was studied. Acid secretion and PGE2 release into the gastric lumen were both stimulated by subcutaneous injection of tetragastrin at a dose of 4μg/kg and were reached to peak levels during 20-30 min after the injection. Acid secretion and the release of PGE2 were significantly increased although PGE2/H+ ratio was tend to decrease during 60 min after the tetragastrin injection. There was correlation between acid secretion and the release of PGE2 after the tetragastrin injection. These results suggest that tetragastrin stimulated the release of PGE2 into the gastric lumen although this is less predominant than its stimulating effect on acid secretion. This phenomenon seems to be important to elucidate the role of tetragastrin on gastric mucosal functions.