:Effect of β-Cyclodextrin clathrate of 2-Benzyloxycarbonylphenyl trans-4-guanidinomethylcyclohexanecarboxylate hydrocholine (TA903) on Mucosal Prostaglandins

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Endogenous prostaglandins (PGs) exert"adaptive cytoprotection"against various irritation in gastric mucosa suggesting the importance of their physiological role. Therefore, it is necessary to investigate the stimulatory factors on PG synthesis in gastric mucosa. In this study, we investigated the effect of β-cyclodextrin clathrate of 2-benzyloxycarbonylphenyl trans-4-guanidinomethylcylcohexanecarboxylate hydrochloride (TA903), which exerts an antiulcer effect on various experimental ulcer models, on the PGE2 and PGI2 levels in rat gastric mucosa under the treatment with indomethacin or water-immersion. In these results, TA903 inhibited the decrease of mucosal PGE2 and PGI2 induced by indomethacin or water-immersion, suggesting that the stimulation of PG synthesis is one of the mechanisms of its antiulcer effect.
財団法人日本消化器病学会の論文