潰瘍性大腸炎患者の糞便細菌叢に関する研究

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Faecal microflora in patients with ulcerative colitis were studied with respect to stool condition, stage and severity of the disease, Moreover, faecal microflora were compared between first relapsing cases under maintenance treatments and untreated cases.Counts of obligate anaerobes were significantly decreased irrespectively of stool condition, stage and severity of the disease. The frequenices of detection of obligate anaerobes were much lower particularly in severe cases and cases with bloody diarrhoea. Specifically the counts and frequencies of detection of bifidobacteria reflected the severity of the disease. Further, in the genera of the Enterobacteriaceae Eschrichia coli was not isolated and Proteus, which was not isolated from faeces of the healthy controls, was often isolated and became dominant in severe cases. These findings suggest the presence of abnormal microflora in the gut of patients with ulcerative colitis. Faculative anaerobes, especially streptococci were increased more markedly in first relapsing cases compared with untreated cases.
財団法人日本消化器病学会の論文