The effects of omeprazole, a proton pump inhibitor, on gastric mucosa, serum gastrin and pepsinogen activity of the rats, with special reference to neonatal development.

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The effects of omeprazole, a proton pump inhibitor, on the secretion of acid and pepsin in Wistar rats of 4-W age were studied by a subcutaneous injection, and that on the neonatal development of gastric mucosa was also evaluated by long term administration of omeprazole (s.c) in new born rats. Single subcutaneous administration of omeprazole showed dose-dependent inhibition on acid secretion in 4w rats, particularly, 50mg/kg omeprazole produced total inhibition for 72 hours. Omeprazole also inhibited pepsin secretion. Four weeks administration of 50mg/kg omeprazole to new born rats caused 1) marked vacuolar degeneration of fundic mucosa with eosinophilic change of chief cells, 2) marked increase of serum gastrin levels, and 3) significant increase of pepinogen proteolytic activity of fundic mucosa. These changes were confirmed to be transient and reversible after cessation of the administration.
財団法人日本消化器病学会の論文