The role of the liver in normal immune responses.

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概要

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• The role of the normal liver in immune responses to a gut-derived antigen was investigated. Guinea pigs were immunized with dinitrochlorobenzene (DNCB) in Freund's complete adjuvant. Immune responses were determined by measuring the level of delayed type hypersensitivity and serum concentration of anti-DNP antibodies.1) Feeding DNCB before sensitization to this agent significantly depressed both contact reaction to DNCB and anti-DNP antibody response, but a decrease in the level of tuberculin hypersensitivity was not seen. These results confirm the work of Chase, as well as that of Sulzberger.2) To investigate the role of the normal liver in the induction of oral tolerance, DNCB was injected into either the mesenteric veins or peripheral veins prior to sensitization. A significant decrease in the level of contact sensitivity was seen in the injections of DNCB into the mesenteric veins when compared with that obtained following similar injection into the peripheral veins, but anti-DNP antibody production was not clearly depressed.These results suggest that the normal liver might play an important role in the Chase-Sulzberger phenomenon.

• 財団法人 日本消化器病学会の論文

著者

• 畔上 信久

  東京医科歯科大学医学部第三内科

• 畔上 信久

  東京医科歯科大学第3内科

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• The role of the liver in normal immune responses.

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