:Measurement of basal flow and its changes during food intake

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The dynamics of canine pancreatic blood flow were observed in the conscious state. Basal pancreatic blood flow under fasting and non-stimulus states was measured by the hydrogen gas clearance method. Pancreatic blood flow changes during meat meal ingestion were observed by the heated thermocouple method. Measurement in both methods was done by means of a tiny atraumatic element inserted into the pancreas.The basal pancreatic blood flow was 50.7±17.3ml/min/100g in the conscious state. Various factors influencing basal pancreatic blood flow were analyzed by multivariate analysis, which showed that a intravenous pentobarbital injection (25mg/kg) caused a significant depression of the blood flow.A pancreatic blood flow increment (maximum, 65%) immediately occured following meat meal ingestion. This increment returned slowly to the basal line over a period of 1-2 hours. In about half the animals, this response was biphasic, suggesting that the pancreatic blood flow response after food intake was composed of multiple factors.
財団法人日本消化器病学会の論文