STUDIES ON PANCREATIC BLOOD FLOW IN CONSCIOUS DOGS (III):Role of the gastric and intestinal phases

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The role of the gastric and intestinal phases with regards to pancreatic blood flow were observed by the heated thermocouple method using conscious dogs in which a tiny atraumatic element had been implanted in the pancreas. Pancreatic blood flow was observed during intragastric or intraduodenal instillation and gastric or duodenal dilatation in these dogs.Analogous pancreatic blood flow increments were observed after intragastric instillation of 5% meat soup, 1M glysine and normal saline. A pancreatic blood flow increment was also observed by mechanical gastric dilatation and the duration of this response coincided with that of gastric dilatation.A pancreatic blood flow increment occured after intraduodenal HCl instillation. Duodenal dilatation also induced a pancreatc blood flow increment.From these observations, it is supposed that the pancreatic blood flow was mainly regulated by a neural mechanism (the gastropancreatic reflex) from the stomach and by neural as well as hormonal (secretin) mechanism from the duodenum in the conscious state.
財団法人日本消化器病学会の論文