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The intravenous administration of synthetic porcine GRP (pGRP) in the dog caused significant decrease of blood flow rates in celiac and superior mesenteric arteries with a transient increase in femoral artery. Atropine did not affect the stimulant action of pGRP on these arterial blood flow. The decrease of the superior mesenteric arterial blood flow by pGRP was dose-dependent both in the maximal reduction rate and the integrated reduction rate at the doses between 3.75 and 480pmol/kg i.v. bolus. Comparing the action of systemically synthesized pGRP and its related peptides upon the canine superior mesenteric arterial blood flow, one could conclude that the C-terminal octapeptide of pGRP was the vital active core of pGRP. The N-terminal tridecapeptide of pGRP was inactive upon the blood flow of superior mesenteric artery, but it seemed to be important for the full activity of pGRP.
財団法人日本消化器病学会の論文