:Mainly in the cases of chronic hepatitis

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Using nonoclonal antibodies, OKT series, Con A induced suppressor activity was investigated. The subsets of peripheral blood lymphocytes were evaluated by means of the method of immunofluorosecence with monoclonal antibidies in healthy subjects and patients with chronic hepatitis.Con A induced suppressor activity was observed not only in unfractionated lymphocytes but in OKT4 subset (-) fraction and OKT8 subset (-) fraction. These findings were compared between healthy subjects and patients with chronic hepatitis, but no statistically significant difference was found.After the induction of suppressor cells by Con A, using peripheral blood lymphocytes of healthy subjects, OKIal (-) subset showed increased suppressor activity as compared with OKIal (+) subset.In patients with CAH, no difference of the percentages of OKT3+ Tcell and OKT4+ Tcell was obtained, however the percentages of OKT8+ Tcell were significantly decreased and the ratios of OKT4+ Tcell and OKT8+ Tcell, OKT4/OKT8, were elavated compared to healthy subjects.From these results, it could be concluded as follows:(1) suppressor cells induced by Con A have no Ia-antigen on their cell membrane, (2) the decreased percentages of suppressor cells may be involved in the pathogenesis in patients with CAH.
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