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The effect of biliary diversion on the inhibition of gastric secretion by fat in dogs with Heidenhain pouch and Mann-Bollman's duodenal fistula was studied. Biliary diversion was created by the operative procedure; that was ligation, division of the distal common bile duct and construction of Roux-en Y cholecystojejunostomy.Amogastrin-stimulated acid secretion of Heidenhain pouch was significantly reduced by the intraduodenal corn oil infusion in control dogs. But, in dogs with biliary diversion, this acid secretion was not reduced. However, with the intraduodenal infusion of mixture of corn oil and bile in dogs with biliary diversion similar inhibition of gastric acid secretion was observed as was seen with the intraduodenal infusion of corn oil alone in control dogs.These results suggested that the inhibitory effect of the intraduodenal infusion of fat on gastric acid secretion was significant, but this effect was not seen in the absence of bile, and that the gastric acid hypersecretion induced by biliary diversion might be due to the inaction of the inhibitory mechanisms of gastric secretion by fat.
財団法人日本消化器病学会の論文