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Hyperamylasemia was observed in 17 out of 95 cases of ulcerative colitis followed at Yokohama City University Hospital. Seven out of 17 cases revealed persisting hyperamylasemia. Hyperamylasemia was seen more frequently in patients with total colitis, but not related to severity of the disease and the previous history of operation to colitis. In cases with persisting hyperamylasemia, both serum pancreatic and salivary amylase isozymes were elevated but amylase creatinine clearance ratio was almost normal. Acute pancreatitis, hepatobiliary diseases, disease of salivary gland and macroamylasemia were neglected from clinical and other laboratory findings. The cause of hyperamylasmia in ulcerative colitis was unknown, but several factors were speculated such as sulphasalazine and steroid therapy, production of amylase by intestinal bacteria and intestinal epithelial cells.
財団法人日本消化器病学会の論文