インシュリン低血糖刺激によるガストリン放出機序におけるカテコールアミンの役割に関する研究.

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The author studied the mechanism of gastrin release during insulin-induced hypoglycemia by 5 series of experiments using dogs; (1) control group, (2) truncal vagotomized group, (3) surgical sympathectomized group, (4) truncal vagotomized with surgical sympathectomized group, (5) bilateral adrenalectomized group. Each group consisted of 5 dogseach. And the highest adrenal eqinephrine secretion rate under insulin hypoglycemia was analyzed in 5 control dogs.Serum gastrin and plasma catecholamines were measured periodically before and after insulin. administration. There was a strong correlation between serum gastrin and plasma epinehrine responses except bilateral darenalectomized group. In that group, both serum gastrin and plasma epinephrine responses were significantly suppressed.In the other experiments, epinephrine was infused intravenously in amounts of the highest adrenal epinephrine secretion rate. There was a significant correlation between serum gastrin response and plasma epinephrine concentration. Propranolol eliminated the gastrin response to epinephrine, and POB caused no alteration.Thus, the author concluded that the release of gastrin during insulin-induced hypoglycemia is mainly intermediated by epinephrine secreted from the adrenal glands.
財団法人日本消化器病学会の論文