THE RESPONSE OF GASTRIC ACID SECRETION AND GASTRIN RELEASE TO INSULIN HYPOGLYCEMIA IN PATIENTS WITH DUODENAL ULCER

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This study examined the method of vagal stimulation by insulin hypoglycemia to determine the relation between peripheral vein blood gastrin concentration and gastric aicd secretion.Gastric acid and serum gastrin responses to insulin hypoglycemia with or without medical vagotomy were measured in 49 duodenal ulcer patients. Serum gastrin responses to insulin hypoglycemia rose significantly at 30 minutes, and gastric aicd secretion responded early after insulin injection. Serum gastrin responses to insulin hypoglycemia after medical vagotomy rose similarly at 30 minutes in the cases of insulin hypoglycemia only, but gastric acid secretion were significantly inhibited. These findings indicated that the gastrin release during insulin hypoglycemia is less important in stimulating acid seretion than the direct action of the vagus on the parietal cell, and the release of gastrin by insulin hypoglycemia does not depend soley on the vagus. The greater part of the release of gastrin may depend on the posterior hypothalamo-sympathetic nerve system.
財団法人日本消化器病学会の論文