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In 50 subjects with liver cirrhosis lower esophageal sphincter (L.E.S.) function was evaluated by measuring basal LES pressure (LESP) and LES response to the administration of intravenous tetragastrin or oral glycine, concerning to evaluate the presence of gastroesophageal reflux. Basal LESP in liver cirrhosis was not significantly different from that of 16 healthy controls. There was no correlation between basal LESP and serum concentration of endogenous gastrin, estrone or progesterone. However basal LESP significantly increased up to 244±45 mmH2O in patients with histroy of variceal bleeding. It was suggested that anatomical factors such as variceal form, protal hypertension and/or ascites were attributed to this rise of basal LESP. No response of LESP to exogenous gastrin administration was recognized in 9 of 36 cases with liver cirrhosis. Also the decrease of LESP response to oral glycine administration was significant in liver cirrhosis.These data indicated that the gastroesophageal reflux would easily appear more frequently in patients with liver cirrhosis than healthy controls. Therefore the accurate evaluation of LES function should be done by studying the changes of LESP in various stimulation tests.
財団法人日本消化器病学会の論文