:Role of ADCC mechanism

スポンサーリンク

概要

• 論文の詳細を見る

• Lymphocyte cytotoxicity against rat colon epithelial cells which share the antigen-specificity with the human colon was examined in 30 cases of ulcerative colitis, using the 51Cr-release cytotoxicity assay. Lymphocyte cytotoxicity against rat colon cells was observed in the cases of ulcerative colitis, esp, in the active stage. This cytotoxicity was revealed to be mainly mediated by non-T cells. Antibody dependent cell-mediated cytotoxicity against the colon cells was seen, using the sera of the patients and lymphocytes from healthy individual in the assay. The presence of anti-colon antibodies in these sera was demonstrated by analysis of the colon cells treated with the sera on a fluorescence activated cell sorter. All these results suggest that the mechanism of ADCC should play an important role in the destruction of the colonic cells in ulcerative colitis patients.

• 財団法人 日本消化器病学会の論文

著者

• 相磯 貞和

  慶応義塾大学 医学部産婦人科

関連論文

• γ-Seminoproteinに対するモノクローナル抗体の研究
• 209 消化管神経細胞の発生に関する研究
• ALP-およびLDH-結合性免疫グロブリンを同時に証明した潰瘍性大腸炎の1例
• Toxic megacolon 7症例の内科的治療経験
• Monoclonal antibodyを用いた潰瘍性大腸炎における末梢血リンパ球subsetおよびlymphocytophilic antibodyの解析
• 潰瘍性大腸炎における腸管外合併症の検討
• MS2-5 ヒトIL-3/GM-CSFトランスジェニックNOGマウスを用いたヒトアレルギーモデルの確立(MS2 動物モデル,ミニシンポジウム,第62回日本アレルギー学会秋季学術大会)
• HYPOTONIC DUODENOGRAPHY WITH THE USE OF GLUCAGON
• :Role of ADCC mechanism

スポンサーリンク