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The present study was undertaken to evaluate the content of immunoreactive somatostatin(IRS) in the gastric specimens obtained by either gastrectomy or biopsy from the patientswith gastric ulcer or with duodenal ulcer. The IRS content was measured in acetic extractsof the specimens using the specific radioimmunoassay for somatostatin.It was found that IRS was widely distributed throughout the mucosa of the region of the antrum to the body in resected stomachs with gastric ulcer. In the case of resected stomachs with duodenal ulcer the distribution pattern of mucosal IRS content was not qualitatively different from that of resected stomachs with gastric ulcer. There was no consistent correlation between the content of IRS and immunoreactive gastrin in the neighbouring portion of the antrum in the resected stomachs.In the biopsy specimens, the contents of mucosal IRS with duodenal ulcer were 590±211 pg/mg tissue (mean±S. E. M.) at the acute stage and 599±188pg/mg tissue at the healing stage, whereas those with gastric ulcer were 257±68pg/mg tissue at the acute stage and 321±133 pg/mg tissue at the healing stage. The values of IRS at each stage of duodenal ulcer had a tendency to be highes than those at each corresponding stage of gastric ulcer, but the difference was not significant.
財団法人日本消化器病学会の論文