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Measurements of continuous changes in intraduodenal pH were carried out by means of a miniature pH electrode inserted into the duodenum through a chronically implanted duodenal cannula in conscious dogs. Gastric motor activity was measured by strain gage force transducers chronically implanted onto the serosal surface of the stomach.It was found that there exist diurnal changes in intraduodenal pH consisting of the three periods; the weak acid period (pH 7.0-4.0), storng acid period (pH 8.3-1.0) and alkaline period (pH 8.3-7.0).These three periods corresponded to those of the three different gastric motor patterns, the digestive, intermediate and interdigestive state. Furthermore, it was indicated that the strong acid period is most adequate for endogenous release of secretin and the alkaline period for motilin release.These findings suggest that control of gut function is closely related to intraduodenal pH changes through endogenous release of gut hormones.
財団法人日本消化器病学会の論文