ELECTRON MICROSCOPIC STUDIES OF THE EXPERIMENTAL GASTRIC CARCINOMA IN DOGS INDUCED BY N-ETHYL-N'-NITRO-N-NITROSOGUANIDINE (ENNG):Ultrastructural cell features of protruded lesions compared with normal (non-neoplastic) gastric mucosa

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Electron microscopic study was made on protruded lesions in canine stomachs induced by oral administration of ENNG.Histology of the lesions consisted of hyperplastic foveolar epithelium, atypical glands of various degrees and well differentiated adenocarcinoma at the top of the lesions and poorly and/or moderately differentiated adenocarcinomas at the base of the lesions. Ultrastructure of non-cancer-bearing gastric mucosa from the dogs fed by ENNG appeared to be identical to that of normal canine gastric mucosa. The fine structure of foveolar hyperplasia was almost identical to normal gastric mucosa expect for being tall in height and dense in granular population with stippling. Almost 90% area in tip of the protruded lesions was occupied by atypical glands.Ultrastructure of atypical glands suggested of an intermediate between foveolar hyperplasia and adenocarcinoma. While at the base of the protruded lesions, there could be noticed moderately differentiated and poorly differentiated lesions interlaced.In well and moderately differentiated adenocarcinomas, there were distinct tight junctions, and the secretory granules were sparse in population, devoid of stippling, and low in electron density, while in poorly differentiated adenocarcinoma, intercellular connections were loose and the granules were dense in population, lack in stippling, and with various electron density.
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