Experimental Pancreatic Lithiasis

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Little is known about the pathogenesis of pancreatic lithiasis and there has been noreport succeeded in producing pancreatic lithiasis in experimental animals. Incomplete orcomplete obstruction of the pancreatic duct was produced by ligating the duct in adultmongrel dogs and long term observation was made for the purpose of creating experimentalpancreatic lithiasis and elucidating the mechanism of pancreatic calculus formation. Theresults were as follows:1. Pancreatic lithiasis was obtained in six dogs among 13 experiments observed longerthan six months after incomplete ductal obstruction, the incidence was 46 per cent. Noneof the dogs with complete obstruction developed pancreatic lithiasis.2. The calculi were analized to be composed principally of calcium carbonate with amixture of calcium phosphate and organic bodies, which was extremely resembled to thehuman pancreatic calculi.3. The main duct of the pancreas with calculi showed marked tortuous dilatationassociated with stasis of pancreatic juice.4. Significant degrees of diffuse periductal fibrosis and mucoid alterations of the ductalepithelium were histologically noted after incomplete ductal obstruction.As it is plausible, from the results above, that the calculi were formed by calcium precipitationon inspissated mucus which was produced from the altered ductal epithelium, incompleteand prolonged obstruction of the pancreatic duct is concluded to be an importantfactor for pancreatic calculus formation.
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Experimental Pancreatic Lithiasis

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