Immunohistochemical study of the ulcerative colitis:with special reference to the local immunoglobulins

概要

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The tissue immunoglobulins of the surgical specimens obtained from the 12 ulcerativecolitis patients were studied by immunohistochemical and immunoquantitative methods.The results: 1) The mean concentrations of immunoglobulin A, G and M in the colonic mucosawere significantly higher than those of control group. 2) IgA containing cells slightly decreasedin number. 3) The localization of IgA at the apical portion of the epithelial cellwas characteristic of the normal colonic mucosa, however the specimen obtained from thepatients showed a tendency towards an IgA decrease and the interstitial leakage of IgA intothe lamina propria increased. 4) Most of epithelial cells had secretory component, howevera part of the regenerative epithelial lining which accompanied the crypt abscess was depletedof secretory components. 5) These changes suggest disintegration or destruction of the mucosaldefence mechanism.
財団法人日本消化器病学会の論文