EFFECT OF URSODEOXYCHOLIC ACID ON BILIARY LIPID AND BILE ACIDS COMPOSITION IN PATIENTS WITH GALLSTONES:A DOSE-RESPONSE STUDY

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Effect of various doses of Ursodeoxycholic acid [UDCA] (300, 600, 900mg per day) on biliary lipid and bile acids composition was investigated in 15 gallstone patients with functioning gallbladder, using a constant format with ascending dose order. During treatment the effect of UDCA on gallstone dissolution was studied too. At every dose, UDCA therapy improved the lithogenicity of bile significantly (p<0.05). It seemed that this improvement in lithogenicity was associated with a selective reduction in proportion of cholesterol in biliary bile. Optimal dose of UDCA for gallstone dissolution was discussed on the basis of the relationship between percent CDCA+UDCA i.e."chenoid"and lithogenicity. The present study indicates that a dose of 8-12mg/kg or 600mg per day may be necessary to obtain desaturation in patients with gallstones. Nomarked side effect was observed during this study.
財団法人日本消化器病学会の論文