生体内酸化防止剤

概要

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The aerobic organisms are protected from oxygen toxicity by an array of defense systems. They are divided into two categories; one is the preventive antioxidants and the other is the chain -breaking antioxidants. Preventive antioxidants reduce the radical formation. Glutathione peroxidase decomposes, without generation of free radicals, lipid hydroperoxides and hydrogen peroxide which are precursors to peroxyl, alkoxyl, hydroperoxyl and hydroxyl radicals. Catalase decomposes hydrogen peroxide. Proteins such as transferrin chelate and deactivate metal ions. On the other hand, the chain-breaking antioxidants such as vitamin E and vitamin C scavenge peroxyl radicals and interrupt the chain oxidation. The antioxidant activity and efficacy are determined not only by its inherent reactivity but also by its local concentration at specific micro-environment where the oxygen toxicity is taking place.
社団法人日本油化学会の論文