2- [N-アルキル-N- (エチルチオ) チオカルボニルアミノ] -1-エタンスルホン酸ナトリウムの合成とその物理化学的性質及び抗微生物性

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The title compounds (4) (alkyl=n-C10H21, n-C12H25, n-C14H29 and n-C16H33), were prepared by reactions of N-alkyltaurines (3) with carbon disulfide, followed by ethylation with bromoethane (Scheme-1, Table-1). The critical micelle concentrations of their aqueous solutions were determined by surface tension and electric conductivity (Table-2, Fig.-1 and 2).Dispersion, emulsifying, and solubilization powers were also measured using calcium carbonate, liquid paraffin, and Orange OT, respectively (Fig.-4, 5, and 6). The results indicated good surface-active properties of (4), which became better with increasing alkyl chain length except for emulsifying power. Although the compounds (4) were inactive against the gram-negative bacterium, Escherichia coli, good inhibitory effects were observed against the gram-positive bacterium, Staphylococcus aureus and the fungus, Aspergillus oryzae, particularly in the cases of R 10- (4) and R 12- (4) (Table-3 and 4, Fig.-7).
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