二酸化窒素亜急性暴露がラットの動脈血pHa,Paco2,Pao2に及ぼす影響

概要

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To clarify the effect of subchronic nitrogen dioxide exposure on arterial blood pHa, PaCO2 and PaO2, rats were exposed continuously to NO2 at concentrations of 0.4, 1.2 and 4.0ppm for 1, 2 and 3 months. Body weight, heart rate (HR), respiratory rate (RR), blood hemoglobin, arterial blood pHa, PaCO2 and PaO2 were measured for exposed rats and controls. The weights of rats exposed for 1 and 2 months were slightly greater than that of controls, however those of rats exposed to 4.0ppm for 3 months decreased to a level 92% of the control group. The HR's of rats exposed to 1.2 and 4.0ppm for 1 month were significantly reduced, although for animals exposed for 2 or 3 months HR's were equal to control levels. The RR's of rats exposed to 4.0ppm for 2 and 3 months were 109-111% of control levels. The blood hemoglobin in exposed rats was slightly elevated, but not to a significant degree. When rats were exposed to 4.0ppm NO2 for 3 months, the PaCO2 increased slightly, but the PaO2 dropped to 90% of control. The reduced PaO2 which is dependent on NO2 concentration was evident in rats exposed to NO2 for 3 months. Under anesthesia and artificial ventilation, when rats were exposed to 4.0ppm for 3 months, the increase in PaO2 plus the increase in artifical respiratory rate was significantly lower than for control group.
日本衛生学会の論文