ヒドラジン化合物の突然変異誘起性に関する研究,とくに発がん性との関係について

概要

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Hydrazine and its derivatives are widely used in industrial, agricultural and medical fields, but they also exist in nature, for example, in the mushroom or tobacco and tobacco smoke. Therefore, it is important to investigate the mutagenic and carcinogenic effects of hydrazine derivatives.The microbial mutagenicity of 26 hydrazine compounds were tested with Salmonella typhimurium TA98, TA100 and TA1537 in the presence or absence of S-9 Mix. Eighteen of these 26 compounds were already found to be carcinogenic, but the carcinogenicity of 8 of these compounds are yet unknown.1) Five carcinogenic compounds, such as 2-hydroxyethylhydrazine, butylhydrazine oxalate, phenylhydrazine HCl, beta-phenylethylhydrazine sulfate and p-tolylhydrazine HCl, were found to be mutagenic to TA100 with and without S-9 Mix, and 2 of these compounds, hydrazine hydrate and hydrazine sulfate, were mutagenic to TA100 only in the presence of S-9 Mix.2) 2, 4-Dinitrophenylhydrazine and p, p'-oxybisbenzendisulfonylhydrazide, the carcinogenicity of which is unknown, were mutagenic to TA100 with and without S-9 Mix.3) Phenylhydrazine HCl, p-tolylhydrazine HCl and 2, 4-dinitrophenylhydrazine were mutagenic to TA1537 with and without S-9 Mix.4) Phenylhydrazine HCl and p-tolylhydrazine HCl were mutagenic to TA98 with S-9 Mix, while 2, 4-dinitrophenylhydrazine showed mutagenic activity to TA98 with and without S-9 Mix.
日本衛生学会の論文