家兎における銅投与の影響

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The authors have investigated on the effect of long-term orally administered copper to rabbits. Rabbits fed with solid feed stuff containing 0.5%, 0.1%, and 0.02% of neutral acetic copper for twelve to twenty-four months were used for this experiment.Histopathological study indicated that injurous changes of the copper were noticed in the liver and brain of rabbits fed with 0.5% and 0.1% of neutral acetic copper. In the liver, accumulation of copper and iron granules in hepatic cells located chiefly in the peripheral zone of lobuli, periportal fibrosis and mononuclear cell infiltration in the Glissons sheath were the note-worthy findings. In the brain, Alzheimer II type of astroglia revealed scattered throughout and degeneration of small nerve cells associated with satellitosis were recognized. Even the remarkable individual difference in the degree of the pathological changes was observed, the changes described above were most predominant in rabbits fed with 0.5% neutral acetic copper.
日本衛生学会の論文