Effect of environmental temperature on urinary glucuronic acid of rabbits

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The present studies were made on the influence of thermal stress upon excretion of urinary glucuronic acid in male albino rabbits, weighing 2.5 to 4.6 kg. The animals were divided into two groups. One group was used for the experiment on seasonal variation. The other group was remained in chamber, where temperature could be controlled artificially, in order to study the responses by exposure to heat and cold.Analyses of urinary glucuronic acid and ether glucuronide (OG) were carried out by the naphtoresorcin picrate method. The concentration of urinary glucuronic acid was expressed as G/C ratio in urine. Principal results were as follows.1) G/C ratio in urine decreased markedly during the period from July to September. It was, on the contrary, found to increase during mid-winter, from December to February. There was a significant (P<0.05) inverse relationship between environmental temperature and G/C ratio in urine.2) The fluctuation of OG/G ratio in urine could not be observed through the year. Namely, it seemed to be kept at the normal range even in summer.3) After exposure to cold stress (about 10°C) for three days in summer, G/C ratio in urine increased rapidly and returned to the range of pre-experimental levels after cessation of exposure.4) After exposure to heat stress (about 30°C) for three days in winter, G/C ratio in urine decreased and returned to the winter values after cassation of exposure.
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