ウサギの尿中グルクロン酸排泄に対する二硫化炭素,ベンゾール及び鉛化合物の影響

スポンサーリンク

概要

• 論文の詳細を見る

• The importance of glucuronic acid in the detoxication mechanisms has been widely recognized. The present experiments were made with rabbits which were exposed to carbon disulfide, benzol and lead, which are usually used in the todays Japanese industry. An exposing chamber for carbon disulfide was designed so as to regulate its concentration as high as 500ppm. The animals were divided into three groups and each group was exposed twice with a single exposure duration of 3, 6.5 and 12 hours. In order to induce lead and benzol absorption, the animals were injected subcutaneously twice with lead acetate solution, corresponding to 10mg/kg for lead and once with 176mg/kg of benzol respectively.Analyses of urinary glucuronic acid and ether glucronide were carried out by the naphtoresorcin picrate method. The concentration of urinary glucuronic acid was corrected by the concentration of urinary creatinine. Thus the concentration of glucuronic acid was expressed as G/C ratio in urine. Principal results obtained were as follows.1) After inhalation of carbon disulfide, G/C ratio in urine began to decrease rapidly and returned slowly to the normal range in about a week after cessation on inhalation.2) The plasma cholesterol level and A/G ratio as well as GPT of the serum were little varied even after 12 hour inhalation of carbon disulfide. From these facts, it would be suggested that the decreased excretion of urinary glucuronic acid is not due to the impairement of the liver by carbon disulfide, but may be due to other, perhaps, neurological or endocrinological mechanisms.3) The increase of G/C ratio in urine was found in the case of administration of benzol.4) No change concerning the excretion of urinary glucuronic acid was resulted by administration of lead.

• 日本衛生学会の論文

著者

• 近藤 東郎

  慶大医学部衛生学教室

• 桜井 治彦

  慶大医学部衛生学公衆衛生学教室

• 原島 進

  慶大医学部

• 里和 スミヱ

  慶大医学部衛生学公衆衛生学教室

• 近藤 東郎

  慶大医学部衛生学公衆衛生学教室

• 原島 進

  慶大医学部衛生学公衆衛生学教室

• 近藤 東郎

  慶大医学部衛生学・公衆衛生学教室

関連論文

• 特殊健診 (第32回日本産業医学会シンポジアム)
• 潜在性二硫化炭素中毒における呼吸中枢の態度に関する実験的研究
• 試験管内脱水素酵素法による塵粉毒性の研究, J. Marks et al, Study of the Dust with Use of the in vitro Dehydrogenase Technique, A.M.A. Arch. of Ind. Health, 20(5) 383-389,1959
• 29 ニトログリコール作業者の血漿酵素変動に関する研究
• 4. 衛生学・公衆衛生学教育者の立場から (医科大学における衛生学公衆衛生学教育は如何にあるべきか)
• ウサギの尿中グルクロン酸排泄に対する二硫化炭素,ベンゾール及び鉛化合物の影響
• 肺滑石症について, Messite,J.et al, Pulmonary Talcosis,a clinical and enviromental study.A.M.A. Arch.of Ind. Health, 20, 408,1959
• Effect of environmental temperature on urinary glucuronic acid of rabbits
• ウサギの尿中グルクロン酸排泄に対するトルエン,キシレン及び二硫化炭素の影響

スポンサーリンク