メチル水銀投与ラットの脳内水銀分布と脳内アミンの変動

概要

論文の詳細を見る
The present study was proposed to investigate the possible involvement of brain monoamines in the manifestations of the central nervous system (CNS) toxicity of methylmercury chloride (MMC) in rats. Therefore, after 3 or 6 successive subcutaneous injections of 10mgMMC/kg body weight, the accumulation of MMC and the simultaneous changes of monoamines in the various brain regions were observed. The results can be summarized as follows: 1) Mercury was shown to accumulate most rapidly in the substantia nigra but, at the time when paralysis was observed as hind leg crossing, appeared to be highest in the cerebral cortex and the striatum. 2) Norepinephirine levels decreased in all the regions; however, the decreases were more marked in the cerebral cortex and pons+medulla. 3) Dopamine levels decreased only in the substantia nigra. No changes were shown in other regions. 4) Serotonin levels increased in the hypothalamus, striatum, hippocampus and olfactory bulb. Thus, it may be suggested that regional and temporal differences in accumulation could explain the changes of biogenic monoamine levels in MMC administered rats.
日本衛生学会の論文