低濃度鉛暴露新生仔ラットの自発行動量と体内蓄積量について

概要

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Lead was initially transmitted through mothers milk until weaning, then was mixed directly into the diet of the experimental animals after weaning. The effects on rats of post-natal indirect exposure to low levels of lead were evaluated based on locomotor activity, body weight, and time-dependent changes in lead concentration. Throughout the experiment, there were no deaths due to lead exposure, but growth was slightly retarded.Locomotor activity levels were measured daily from the date of weaning until the 56th day. Time-dependent changes of lead-treated rats were significantly lower than those of controls matched by age (p<0.01).The mean lead concentrations in the blood of treated rats reached a maximum of 336.7μg/100g at 14 days, in the brain of 111.4μg/100g at 21 days, in the liver of 698.6μg/100g at 7 days, and in the kidneys at 793.2μg/100g at 14 days. All of the above concentrations decreased steadily until the 56th day. Although lead poisoning is thought to induce several serious behavioral problems, a causal relationship between lead ingestion and behavioral dysfunction has not been demonstrated here.
日本衛生学会の論文