喫煙と血清中Leukotriene B4の関係
スポンサーリンク
概要
- 論文の詳細を見る
Leukotriene B4 (LTB4), an arachidonic acid metabolite released by neutrophils, is involved in the regulation of the host immune response to antigenic stimulation. Furthermore, LTB4 affects the chemokinesis, aggregation, and enzyme release of neutrophils and stimulates activity of cytotoxic T cells, natural killer cells and suppressor T cells.On the other hand, smoking typically results in inflammatory stimulation of the lung, and long-term smoking can cause chronic stimulation.In this paper, we report the measurement of LTB4, IgG, IgA, IgM, IgD and IgE in sera of cigarette smokers who did not have an allergic reaction (group 1), non-smokers who also had no history of allergy (group 2) and non-smokers who had delicate allergic conditions (group 3). The mean LTB4 concentration in serum of group 1 was nearly 3.3-fold greater than in group 2 and 2-fold greater than in group 3, being 430±55 (Mean±S. D.), 130±22 and 220±14pg/ml, respectively. Concentrations of IgG, IgA, IgM, IgD and IgE of all volunteers were in the normal healthy range. The mean concentration of IgE in the serum of group 1 did not change significantly within one day. It was 35±4IU/ml in the morning, 34±4IU/ml in the afternoon, 31±2IU/ml in the evening and 32±4IU/ml the next morning. But in group 3 the IgE concentration changed significantly within one day, being<25IU/ml in the morning, 97±7IU/ml in the afternoon, 97±7IU/ml in the evening and 25±14IU/ml the next morning. The IgE concentration in the serum of group 2 showed the same tendency as group 3. For all groups the LTB4 concentration in the serum changed during the day, that is LTB4 in the afternoon was higher than LTB4 in the morning. But the LTB4 in the evening was almost the same as in the morning, and remained so until the next morning.We also measured nicotine and its metabolites in each volunteers urine. We could detect nicotine and its metabolite, cotinine in urine of group 1, and a slight quantity of nocotine in urine of group 2 and group 3.Thus, it appears that the production and release of LTB4 are promoted by antigens which are inhaled through smoking and that LTB4 can be increased in serum by passive smoking as can IgE.
- 日本衛生学会の論文
著者
関連論文
- Hp Johnson 型の alpha サブユニットの遺伝子解析
- IgG型M-蛋白血症患者血清の免疫電気泳動における正常IgG出現の機序
- 二次元親和電気泳動法を用いたハプトグロビンポリマーのヘモグロビンとの親和力の推定
- ヘモグロビン分子のヘム解離および保持に関するハプトグロビンの役割
- 新生児ハプトグロビンの定量と型判別の問題点
- ポリアクリルアミドゲル電気泳動によるメトヘムアルブミンの検出
- 縊死による局部病変の形態学的研究
- タイトル無し
- rac-methamphetamineを接種した実験動物における諸種覚せい剤の生体内分布
- Velta Vorksone, Grigory Vabels:ドイツ貴婦人・ロバのミトコンドリアDNA鑑定
- 最後のロシア皇帝Nicolas 2世の実兄,Georgij RomanovのDNA鑑定:ミトコンドリアDNAの塩基配列
- 屍〓中に存在するC18:1およびC16:1の異性体分析
- メタンフェタミン塩酸塩の赤外吸収スペクトル測定法に関する一考察
- ウシ血清アルブミンとmethamphetamineの結合反応に関する基礎的研究
- 喫煙と血清中Leukotriene B4の関係
- 喫煙と血清中Leukotriene B4の関係
- 血液型抗原分析用レクチンを用いたC群Streptococcusの同定