ウシ血清アルブミンとmethamphetamineの結合反応に関する基礎的研究

概要

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We studied the binding between bovine serum albumin (BSA) and methamphetamine (MAMP) with the ultra filtration method. Under the conditions employed by this study, the reaction requires the incubation for 18h at 37℃ to be equilibrated. The pattern of Scatchard plot of the binding reaction between BSA and MAMP was biphasic. The results suggest that BSA had two binding sites for MAMP ; the binding constant and the maximal binding of MAMP to BSA in classes I and II bindings were 216.9×10^3 M^<-1> and 0.2,and 0.1×10^3M^<-1> and 14.9,respectively.
公益社団法人日本薬学会の論文
1995-04-30