BIOCHEMICAL STUDIES ON HUMAN SALIVARY PROTEINS III. AMINO ACID COMPOSITION AND STABILITY OF THE HYPOCALCEMIC FRACTION FROM THE PRONASE DIGEST OF SALIVA-PAROTIN-A
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概要
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Amino acid and carbohydrate analyses and stability examination of the hypocalcemic polypeptide fraction (P-I) separeted from the Pronase digest of saliva-parotin-A were carried out. The contents of amino acids and carbohydrates in P-I were found to be 52.43 and 20.68%, respectively. Of thirteen kinds of amino acids determined, the high contents of glutamic acid and proline, which were found to be 12.32 and 20.59%, respectively, were characteristic. The hypocalcemic and leukocytosis-promoting activities of P-I were eliminated by treatments with heat, HCl, NaOH, urea and nitrous acid and weakened with nitrogen mustard. These chemical properies of P-I were different from those of the purified saliva-parotin-A.
- 社団法人 日本内分泌学会の論文
著者
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Ueki Hiroshi
Department Of Biochemistry Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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KUBOTA YUKIHO
Department of Physiological Chemistry Faculty of Pharmaceutical Sciences, University of Tokyo
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HARA YOSUKE
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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KUBOTA YUKIHO
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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- BIOCHEMICAL STUDIES ON HUMAN SALIVARY PROTEINS III. AMINO ACID COMPOSITION AND STABILITY OF THE HYPOCALCEMIC FRACTION FROM THE PRONASE DIGEST OF SALIVA-PAROTIN-A