Metabolic Disturbance of KK Mice in Overt Diabetes

概要

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KK mice, which proved to be of chemical diabetes when kept on usual laboratory chow, developed hyperglycemia with hypertrophy of epididymal adipose tissue when fed a semisynthetic diet. Effects of the semisynthetic diet on metabolic activities were investigated <I>in vitro</I>. In adipose tissue, lipogenesis from acetate was markedly activated, but either oxidation of glucose or lipogenesis from glucose was hardly activated. Insulin sensitivity of the tissue was diminished in glucose oxidation, but not in lipogenesis from acetate. Hepatic lipogenesis from both glucose and acetate was markedly stimulated. Thus, activation of hepatic and extrahepatic lipogenesis, and reduction of insulin sensitivity in peripheral glucose metabolism may result in the onset of overt diabetes associated with adiposity.<BR>These metabolic profiles were similar to those of genetically obese KK mice, yellow KK. A possible mechanism of the diabetogenic action of the diet is discussed on the basis of the metabolic defects of KK strain.
社団法人日本内分泌学会の論文