Induction of Overt Diabetes in KK Mice by Dietary Means

スポンサーリンク

概要

• 論文の詳細を見る

• KK mice fed on semisynthetic diets with a usual composition developed marked obesity and diabetic symptoms in comparison with those kept on laboratory chow. The observed changes included obesity, fatty liver, glucosuria, hyperglycemia and degranulation of pancreatic B cells. These changes became more prominent with prolonged period of feedig up to 24 weeks. Among them, fatty liver and obesity were also induced in control ICR mice upon feeding semisynthetic diets but the developments were limited in moderate degree and no diabetic symptom developed. These results indicate that the different response to diets in both mice can be attributed to genetic factors.

• 一般社団法人 日本内分泌学会の論文

著者

• Matsuo Takao

  Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

関連論文

• Metabolic Disturbance of KK Mice in Overt Diabetes
• Induction of Overt Diabetes in KK Mice by Dietary Means
• Antiobesity and Antidiabetic Actions of a New Potent Disaccharidase Inhibitor in Genetically Obese-Diabetic Mice, KKAy.

スポンサーリンク