Influence of the Fornix Section on the Biosynthesis of Ovarian Steroids in the Rabbit

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Influence of the fornix section on the biosynthesis of ovarian steroids, which was indicated by the transfer rates of 14C from 14C-1-acetate into progesterone, 20α-hydroxypregn-4-en-3-one (20α-OH-P) and estrogen (estradiol and estrone) in the ovarian homogenates incubated for 1 h, was studied in the female mature New Zealand white rabbits (2.5-3.0 kg). The animals served the experiment at least 3 to 4 weeks after the operation of sectioning the fornix. The results were as follows: 1) The biosynthesis of progesterone, 20α-OH-P and estrogen decreased markedly (approximately 50%) compared to the nonoperated controls, while the ovarian weight did not change. 2) The estrogen primed animals with the fornix section did copulate but not ovulate. However the biosynthesis of progesterone, 20α-OH and estrogen increased by approximately 100%, indicating the release of ovulating hormone. These results indicate that the elimination of the hippocampal influence to the hypothalamus, in the long-term experiment, markedly reduces the pituitary-ovarian activity.
社団法人日本内分泌学会の論文