Cholinergic and Serotonergic Neural Links and the Inhibitory Effects of Hippocampus, Lateral Amygdala and Central Gray Matter on Gonadotropin Release
スポンサーリンク
概要
- 論文の詳細を見る
Effects of electrical stimulation of the hippocampus (HPC), lateral amygdala (1-AMYG) and midbrain central gray matter (CG) on the release of ovulatory gonadotropin were examined using proestrous Wistar rats with or without pretreatment with reserpine, atropine or p-chlorophenylalanine (PCPA) at such dosage that had been confirmed not to block ovulation. Electrical stimulation of the HPC, 1-AMYG or CG under light ether anesthesia just before the critical period prevented a rise in serum LH, FSH and prolactin levels at 18:00. Pretreatment with atropine (200mg/kg body wt, sc) was effective to abolish this inhibitory effect of the HPC stimulation on the release of LH and FSH, whereas reserpine treatment (1mg/kg body wt, ip) did not affect the effect. The inhibitory effect of the 1-AMYG or CG stimulation on LH and FSH release was abolished by treatment with PCPA (150 mg/kg body wt, ip), while neither atropine nor reserpine had any effect. The inhibitory effect of the HPC stimulation on the release of these hormones was also blocked by PCPA treatment. In regard to the prolactin release, it was inhibited by the stimulation of the HPC, 1-AMYG or CG in both the non-treated rat and in the atropine or PCPA-treated one, while in the reserpine-treated rat it was not inhibited but rather was facilitated by these stimulations.<BR>It was assumed that the normal maintenance of both cholinergic and serotonergic neural links for the expression of the HPC inhibition on ovulatory LH, FSH and prolactin secretion and that of serotonergic link for the expression of the 1-AMYG or CG inhibition are needed. The inhibitory action on prolactin release changed into facilitation under the depletion of monoamines, but the mechanism is unknown.
- 社団法人 日本内分泌学会の論文
著者
-
Kimura Fukuko
2nd Dept Of Physiology Yokohama City University School Of Medicine
-
Kawakami Masazumi
2nd Department of Physiology Yokohama City University School of Medicine
-
KAWAGOE SHINNOSUKE
2nd Department of Physiology Yokohama City University School of Medicine
-
KIMURA FUKUKO
2nd Department of Physiology Yokohama City University School of Medicine
関連論文
- Effects of Noradrenaline on GnRH-Secreting Immortalized Hypothalamic (GT1-7) Neurons
- IS-30 Electrophysiological effects of noradrenaline on GnRH neurons
- Brain Mechanisms Involved in Adaptation to the Immobilization Stress
- Effect of Electrical Stimulation of the Medial Preoptic Area on Hypothalamic Multiple Unit Activity in Relation to LH Release
- Localization and Mechanism of Stimulatory Feedback Action of Estrogen: Effect of Limbic Forebrain Implantation of Estradiol Benzoate on Advancement of Ovulation
- Cholinergic and Serotonergic Neural Links and the Inhibitory Effects of Hippocampus, Lateral Amygdala and Central Gray Matter on Gonadotropin Release
- Inhibition of Ovulation in the Rat by Electrical Stimulation of the Lateral Amygdala
- Influence of the Fornix Section on the Biosynthesis of Ovarian Steroids in the Rabbit
- LH Discharge Induced by Medial Preoptic Implantation of Estrone or Dopamine in the Ovariectomized Estradiol Primed Rat
- Stimulatory Feedback Action of Estradiol and Estrone on LH Release in the Ovariectomized Rat: Roles Different between Limbic System and Preoptic Area
- Acute and Chronic Effects of the Fornix Section on Cyclic Gonadotropin Secretion and Ovulation in the Rat
- Electrical Stimulation of the Hippocampus under the Chronic Preparation and Changes of LH, FSH and Prolactin Levels in Serum and Pituitary
- The Roles of Extrahypothalamic and Intrahypothalamic Impulses to the Medial Basal Hypothalamus in the Control of the Pituitary-Gonadal-Axis
- Effects of Ovulation-Blocking Agents upon the Limbichypothalamic Neuronal Pathways in the Rabbit Brain
- Effects of Electrical Stimulation of the Brain on Gonadotropin Secretion in Male Rats
- Effects of Hippocampal Ablation on Stress-Induced Gonadotropin Secretion: An Observation of the Sexual Difference
- Effects of Limbic Forebrain Ablation on Pituitary Gonadal Function in the Female Rat
- Positive Feedback Sites of Estrogen in the Brain on Ovulation : Possible Role of the Bed Nucleus of Stria Terminalis and the Amygdala
- A Possible Role of the Hippocampus and the Amygdala in the Androgenized Rat : Effect of Electrical or Electrochemical Stimulation of the Brain on Gonadotropin Secretion
- Electrical Stimulation of the Brain on Gonadotropin Secretion in the Female Prepuberal Rat
- Acute Effect of Neural Deafferentation on Timing of Gonadotropin Secretion Before Proestrus in the Female Rat
- Further Studies on Sexual Differentiation of the Brain: Response to Electrical Stimulation in Gonadectomized and Estrogen Primed Rats
- Effects of 17α-Hydroxyprogesterone on Luteinizing Hormone Release in the Rat
- Study on the Bed Nucleus of Stria Terminalis in Relation to Gonadotropin Control